Women and cannabis – what’s special?

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It is very important to understand that the endocannabinoid system in men and women is different [1]. Because there is not yet enough linguistic awareness of the effects of using cannabis on men and women, it is often wrong to adapt strains to patients. The expression of CB1 receptors in women’s brains differs from that of men. Researchers have found that there is a difference in corticosteroids in the prophylactic cortex and in amygdala and that the estradiol hormone reduces the number of receptors expressed in these locations.

In the mice it was found that estradiol had an effect on the endocannabinoid system and changed the emotional behavior. There is a connection between the amygdala and the prefrontal cortex that responds to emotional events and the amygdala regulates fear and anxiety responses to events. The same areas of the brain are also responsible for social behavior and concentration. In addition to these differences between the sexes in relation to motivation, reward system and motor activity and all these receptors CB1 type cannabinoids play a crucial role.

More recently, the endocannabinoid system has been studied further in the female body and it has been found that there are many receptors and endocannabinoids in the reproductive system [3]. Levels of anandemide vary during menstruation and early pregnancy. These levels are important during the implantation of pregnancy in the womb. In the mice, endocannabinoids AEA, 2-AG and their enzymes are produced in the womb with a great effect on the hormonal cycle [4]. At peak levels of anandamide in the womb, it has the largest amount in the woman’s body, which may explain why many women choose to consume cannabis for the treatment of premenstrual syndrome (PMS). Women report that cannabis helps with relief of various premenstrual symptoms as well as menopausal symptoms.

Cannabis and sexual desire: Many women report a different effect on cannabis consumption, with an emphasis on dosages. Low consumption stimulates sexual desire and consumption of a high percentage suppresses sexual desire.

Depression: Pre-clinical studies have found that while depression decreases anandamide levels in women’s blood. Women with major clinical depression also have low levels of AG2.

Cannabis for the treatment of breast cancer: Women respond well to phytocannabinoids and to the CBD. Research [5] has found that CBD-rich species have an advantage in breast cancer. It appears that CBD can inhibit cancer cell proliferation and induce mitochondrial leaps through extracellular signal-regulated kinase (ERK) and reactive oxygen species (ROS) pathways, and that both pathways lead to a decrease in Id-1 (a helix-loop helix transcription factors) And therefore as a result of its decline there is less chance of metastasis.

Cannabis for endometriosis: It is very important for women with cannabis endometriosis to know which strains are appropriate. THC in large amounts may cause a worsening of their condition due to increased cell migration [6]. There is an “orphan” antibody called GPR18, which is probably responsible for adenocarcinoma cell migration [7] and is activated by THC. Fortunately CBD inhibits this antibody. Women with endometriosis need cultivars rich in CBD and in any case avoid species rich in THC. It is recommended to select cultivars in relation to 3: 1 CBD: THC.

Eating disorders: It was found that women with anorexia have low levels of anandamide, which is not found in women with bulimia. It turns out that endocannabinoids play an important role in regulating leptin, the hormone of fat that is important in the energy balance and body weight.

addiction? Women of childbearing age may develop dependency on cannabis more than older women, and the cause may be due to estrogen levels and its association with THCA.

Varieties suitable for women:

Fennel-rich and mersin varieties help fight menstrual cramps and cramps in the stomach. It is important to combine CBD with THC to reduce psychoactive side effects.

Zan Kush are rich in mersin, lemonen and cariopylane, good for the evening before bedtime.

During the day, strains are rich in cryophyllan with little THC.

HAZE-based strains are generally excellent for women, since HAZE is a strain developed in Santa Cruz in California in 1970 for women. Easy hayes are good for the day, cause concentration and stimulate good energy. Rich in cryophenyl and their laxative and less virulent, anti-inflammatory, anti-anxiety and depression.

We will conclude with the hope that we will soon receive more information on the tropics in a variety of varieties of medicinal cannabis in Israel.

[1] https://www.sciencedirect.com/science/article/pii/S0024320512003049

[2] https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1038/sj.bjp.0707465

[3] Taylor A, Abbas M, Habiba M, Konje J. Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle. Histochem Cell Biol. 2010;133(5):557-565

[4] Wang H, Xie H, Sun X, et al. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins Other Lipid Mediat. 2007;83(1-2): 62-74

[5] McAllister, S. D., Murase, R., Christian, R. T., Lau, D., Zielinski, A. J., Allison, J., … Desprez, P.-Y. (2011). Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Research and Treatment, 129(1), 37–47. http://doi.org/10.1007/s10549-010-1177-4

[6] Dmitrieva, N., Nagabukuro, H., Resuehr, D., Zhang, G., McAllister, S. L., McGinty, K. A., … Berkley, K. J. (2010). Endocannabinoid involvement in endometriosis. Pain, 151(3), 703–710. http://doi.org/10.1016/j.pain.2010.08.037

[7] McHugh, D., Page, J., Dunn, E., & Bradshaw, H. B. (2012). Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. British Journal of Pharmacology, 165(8), 2414–2424. http://doi.org/10.1111/j.1476-5381.2011.01497.x

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